Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff.
Identifieur interne : 000601 ( Main/Exploration ); précédent : 000600; suivant : 000602Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff.
Auteurs : Pierre Savatier [France] ; Pierre Osteil [Australie] ; Patrick P L. Tam [Australie]Source :
- Stem cell research [ 1876-7753 ] ; 2017.
Abstract
The diverse cell states and in vitro conditions for the derivation and maintenance of the mammalian embryo-derived pluripotent stem cells raise the questions of whether there are multiple states of pluripotency of the stem cells of each species, and if there are innate species-specific variations in the pluripotency state. We will address these questions by taking a snapshot of our knowledge of the properties of the pluripotent stem cells, focusing on the maintenance of pluripotency and inter-conversion of the different types of pluripotent stem cells from rodents, lagomorphs and primates. We conceptualize pluripotent stem cells acquiring a series of cellular states represented as terraces on a slope of descending gradient of pluripotency. We propose that reprogramming pluripotent stem cells from a primed to a naive state is akin to moving upstream over a steep cliff to a higher terrace.
DOI: 10.1016/j.scr.2017.01.008
PubMed: 28126658
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes
- Bron, Sydney
- Université de Sydney
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